Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVE: To investigate the relationships between plasma concentrations of sex hormones and risk factors for breast cancer. METHODS: We investigated the relationship of plasma concentrations of estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) with breast cancer risk factors in 636 premenopausal and 456 postmenopausal women. Risk factor data were obtained from questionnaires and hormone concentrations measured by immunoassays; variations in geometric means were compared using analysis of covariance. RESULTS: SHBG decreased with increasing body mass index and increasing waist-hip ratio both in pre- and postmenopausal women. In postmenopausal women only, estradiol increased with increasing body mass index. In premenopausal women, estradiol decreased with increasing physical activity, estradiol was higher in current than in ex- and non-smokers, and FSH decreased with increasing alcohol intake. No associations were observed between sex hormones and age at menarche, parity, age at menopause, and previous use of oral contraceptives in either pre- or postmenopausal women. CONCLUSIONS: Certain factors such as obesity and perhaps waist-hip ratio, physical activity and alcohol consumption, but probably not age at menarche and parity, may mediate their effects on breast cancer risk by changing circulating concentrations of sex hormones.

Original publication

DOI

10.1023/a:1008929714862

Type

Journal article

Journal

Cancer Causes Control

Publication Date

01/2001

Volume

12

Pages

47 - 59

Keywords

Adult, Aged, Alcohol Drinking, Analysis of Variance, Body Constitution, Body Mass Index, Breast Neoplasms, Cross-Sectional Studies, Estradiol, Exercise, Female, Follicle Stimulating Hormone, Gonadal Steroid Hormones, Humans, Life Style, Luteinizing Hormone, Middle Aged, Obesity, Postmenopause, Premenopause, Progesterone, Risk Factors, Sex Hormone-Binding Globulin, Smoking, Surveys and Questionnaires, United Kingdom