Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.

Original publication

DOI

10.1016/j.ejca.2010.09.029

Type

Journal article

Journal

Eur J Cancer

Publication Date

02/2011

Volume

47

Pages

420 - 427

Keywords

Adult, Aged, Fatty Acid Synthases, Genetic Predisposition to Disease, Genetic Variation, Genotype, Gonadal Steroid Hormones, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, Prostatic Neoplasms, Risk Factors, Somatomedins