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While there is strong epidemiological evidence that circulating insulin-like growth factor-I (IGF-I) is associated with a higher risk of several cancers, little is known about its association with non-cancer outcomes. We investigated associations of circulating IGF-I with risk of 25 common conditions, other than cancer, in a large British cohort. Study participants were 318,749 middle-aged adults enrolled in the UK Biobank Study. Serum IGF-I concentration was measured in samples collected at baseline (2006-2010), and re-measured in 12,334 participants after an average of 4.3 years. We followed-up participants over an average of 11.5 years by linking to hospital admissions and mortality registries. Multivariable-adjusted Cox regressions estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between circulating IGF-I and 25 common conditions, using the repeated IGF-I measurements to correct for regression dilution bias. After correction for multiple testing (P 

Original publication




Journal article


Eur J Epidemiol

Publication Date





25 - 34


Insulin-like growth factor-I, Outcome-wide, Prospective cohort study, Risk, UK Biobank, Adult, Biological Specimen Banks, Humans, Insulin-Like Growth Factor I, Iron Deficiencies, Middle Aged, Noncommunicable Diseases, Prospective Studies, Risk Factors, United Kingdom