Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study.
Crowe FL., Key TJ., Appleby PN., Overvad K., Schmidt EB., Egeberg R., Tjønneland A., Kaaks R., Teucher B., Boeing H., Weikert C., Trichopoulou A., Ouranos V., Valanou E., Masala G., Sieri S., Panico S., Tumino R., Matullo G., Bueno-de-Mesquita HB., Boer JM., Beulens JW., van der Schouw YT., Quirós JR., Buckland G., Sánchez MJ., Dorronsoro M., Huerta JM., Moreno-Iribas C., Hedblad B., Jansson JH., Wennberg P., Khaw KT., Wareham N., Ferrari P., Illner AK., Chuang SC., Norat T., Danesh J., Riboli E.
BACKGROUND/OBJECTIVES: Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study. SUBJECTS/METHODS: Participants were 306,331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall. RESULTS: After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P=0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07). CONCLUSION: A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.