Pancreatic cancer is the fourth leading cause of cancer deaths in the European Union and in the USA, but little is known about its genetic susceptibility. The PANcreatic Disease ReseArch (PANDoRA) consortium was established to unite the efforts of different research groups; its aim is to create a large bio-database to uncover new genetic factors for pancreatic cancer risk, response to treatment, and patient survival. So far 2220 cases of pancreatic adenocarcinoma, a smaller number of cases of endocrine pancreatic tumours (n=86), chronic pancreatitis (n=272) and 3847 healthy controls have been collected. As a collective effort of the consortium, SNPs associated with pancreatic adenocarcinoma risk from a genome-wide association study performed in Caucasians were replicated. The possibility that the same genetic polymorphisms may influence patient survival as well was also addressed. This collective effort is particularly important for pancreatic cancer because it is a relatively rare disease for which little is known about aetiopathogenesis and risk factors. The recruitment of additional collaborators and partner institutions is continuously on-going.

Original publication

DOI

10.1016/j.dld.2012.09.014

Type

Journal article

Journal

Dig Liver Dis

Publication Date

02/2013

Volume

45

Pages

95 - 99

Keywords

Adenocarcinoma, Adult, Aged, Aged, 80 and over, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, Risk Factors