BACKGROUND: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. METHODS: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. RESULTS: We observed no association between IGF-I and EOC overall or by tumour characteristics. CONCLUSIONS: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.

Original publication

DOI

10.1038/bjc.2014.566

Type

Journal article

Journal

Br J Cancer

Publication Date

06/01/2015

Volume

112

Pages

162 - 166

Keywords

Adult, Aged, Case-Control Studies, Cohort Studies, Europe, Female, Humans, Insulin-Like Growth Factor I, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Prospective Studies, Risk