We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Original publication

DOI

10.1038/ng.444

Type

Journal article

Journal

Nat Genet

Publication Date

10/2009

Volume

41

Pages

1055 - 1057

Keywords

Chromosomes, Human, Pair 8, Disease Susceptibility, European Continental Ancestry Group, Genetic Markers, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Factors