Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
Jacobs EJ., Chanock SJ., Fuchs CS., Lacroix A., McWilliams RR., Steplowski E., Stolzenberg-Solomon RZ., Arslan AA., Bueno-de-Mesquita HB., Gross M., Helzlsouer K., Petersen G., Zheng W., Agalliu I., Allen NE., Amundadottir L., Boutron-Ruault MC., Buring JE., Canzian F., Clipp S., Dorronsoro M., Gaziano JM., Giovannucci EL., Hankinson SE., Hartge P., Hoover RN., Hunter DJ., Jacobs KB., Jenab M., Kraft P., Kooperberg C., Lynch SM., Sund M., Mendelsohn JB., Mouw T., Newton CC., Overvad K., Palli D., Peeters PH., Rajkovic A., Shu XO., Thomas G., Tobias GS., Trichopoulos D., Virtamo J., Wactawski-Wende J., Wolpin BM., Yu K., Zeleniuch-Jacquotte A.
A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.