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We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

Original publication

DOI

10.1038/ng.254

Type

Journal article

Journal

Nat Genet

Publication Date

12/2008

Volume

40

Pages

1404 - 1406

Keywords

Apoptosis, Case-Control Studies, Chromosomes, Human, Pair 5, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lung Neoplasms, Membrane Proteins, Neoplasm Proteins, Principal Component Analysis, Smoking, Telomerase