Non-melanoma Skin Cancer and Other Epidermal Tumors

Non-melanoma skin cancer comprises the two most common forms of malignant neoplasms found in humans, namely, basal cell carcinoma and squamous cell carcinoma. Seborrheic keratosis is one of the commonest benign epidermal skin lesions that appear in middle-aged or elderly people. Other common epidermal tumors in this chapter include melanoacanthoma, skin tags, dermatosis papulosa nigra, stucco keratosis, and cutaneous horn. Different types of keratoses will be reviewed such as actinic, lichenoid, and lymphomatoid and keratoses related to chronic exposure to arsenic and tar or after radiation therapy. Also acanthomas, namely, clear cell and large cell, and porokeratoma, an acanthoma with porokeratotic characteristics. Other entities are also disseminated superficial actinic porokeratosis, actinic cheilitis, pseudoepitheliomatous hyperplasia, and HPV-related tumors such as Bowenoid papulosis. Three different rare genodermatoses will be described, namely, nevoid BCC syndrome (Gorlin-Goltz’s syndrome), Rombo syndrome, and xeroderma pigmentosum. It is important to learn how to early recognize and diagnose these tumors and genodermatoses. Based on their characteristic features outlined in this chapter and clinical behavior, clinicians can guarantee patients’ appropriate treatment options with less morbidity, better outcomes, and overall prognosis.