Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer
Established in 2004
Data from 36,000 cases in over 40 studies worldwide
The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group conducts pooled analyses of the relationships between endogenous sex hormones, insulin-like growth factors, nutritional biomarkers and subsequent prostate cancer risk.
The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group conducts pooled analyses of endogenous (natural) hormones and nutritional biomarkers in relation to prostate cancer risk. The group was established in 2004 with its secretariat in the Cancer Epidemiology Unit, and had its first meeting in July 2005 and its second meeting in 2012. Scientists from around 35 studies world-wide are collaborating in this work, and the group is looking at the roles of oestrogens, androgens, growth factors and nutritional factors in the aetiology of prostate cancer. So far the project has collected data from around 23,000 men with prostate cancer and over 30,000 control men for more than 50 biomarkers. The first results were published in 2008 and showed a strong positive association between risk of prostate cancer and levels of the growth hormone IGF-1 (insulin-like growth factor 1) but no significant association of risk with androgens. Several papers on nutritional biomarkers are complete or close to completion, the first of which showed that circulating levels of some fatty acids are moderately associated with prostate cancer risk.