Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort.
Peters S., Gallo V., Vineis P., Middleton LT., Forsgren L., Sacerdote C., Sieri S., Kyrozis A., Chirlaque M-D., Zamora-Ros R., Hansson O., Petersson J., Katzke V., Kühn T., Mokoroa O., Masala G., Ardanaz E., Panico S., Bergmann MM., Key TJ., Weiderpass E., Ferrari P., Vermeulen R.
BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. OBJECTIVE: To assess the associations between alcohol consumption and PD risk. METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD. CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.