AIM: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity. METHODS: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P(interaction)=0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95%CI 1.14-2.91, P(interaction)=0.02). Results were not different in men and women (P(interaction)=0.81). CONCLUSION(S): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention.

Original publication

DOI

10.1016/j.ejca.2013.06.021

Type

Journal article

Journal

Eur J Cancer

Publication Date

11/2013

Volume

49

Pages

3526 - 3536

Keywords

Abdominal obesity, Body weight change, Cancer prevention, Colorectal neoplasms, Adiposity, Adult, Age Factors, Colorectal Neoplasms, Europe, Female, Humans, Incidence, Linear Models, Male, Middle Aged, Multivariate Analysis, Nutritional Status, Obesity, Abdominal, Proportional Hazards Models, Prospective Studies, Risk Assessment, Risk Factors, Risk Reduction Behavior, Time Factors, Waist Circumference, Weight Gain