Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.
Rundle A., Richie J., Steindorf K., Peluso M., Overvad K., Raaschou-Nielsen O., Clavel-Chapelon F., Linseisen JP., Boeing H., Trichopoulou A., Palli D., Krogh V., Tumino R., Panico S., Bueno-De-Mesquita HB., Peeters PH., Lund E., Gonzalez CA., Martinez C., Dorronsoro M., Barricarte A., Tormo MJ., Quiros J., Agudo A., Berglund G., Jarvholm B., Bingham S., Key TJ., Gormally E., Saracci R., Kaaks R., Riboli E., Vineis P.
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.