INTRODUCTION: Epidemiologic evidence for an association between colorectal cancer (CRC) risk and total dietary fat, saturated fat (SF), monounsaturated fat (MUFA) and polyunsaturated fat (PUFA) is inconsistent. Previous studies have used food frequency questionnaires (FFQ) to assess diet, but data from food diaries may be less prone to severe measurement error than data from FFQ. METHODS: We conducted a case-control study nested within seven prospective UK cohort studies, comprising 579 cases of incident CRC and 1996 matched controls. Standardized dietary data from 4- to 7-day food diaries and from FFQ were used to estimate odds ratios for CRC risk associated with intake of fat and subtypes of fat using conditional logistic regression. We also calculated multivariate measurement error corrected odds ratios for CRC using repeated food diary measurements. RESULTS: We observed no associations between intakes of total dietary fat or types of fat and CRC risk, irrespective of whether dietary data were obtained using food diaries or FFQ. CONCLUSION: Our results do not support the hypothesis that intakes of total dietary fat, SF, MUFA or PUFA are linked to risk of CRC.

Original publication

DOI

10.1016/j.canep.2010.07.008

Type

Journal article

Journal

Cancer Epidemiol

Publication Date

10/2010

Volume

34

Pages

562 - 567

Keywords

Case-Control Studies, Cohort Studies, Colorectal Neoplasms, Dietary Fats, Female, Great Britain, Humans, Logistic Models, Male, Middle Aged, Motor Activity, Multivariate Analysis, Prospective Studies