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Archiving

Once the study has ended, it is anticipated that de-identified study data will be archived on NDPH file servers for at least 25 years.

Participating breast screening units

City, Sandwell & Walsall; Dudley & Wolverhampton; Hereford & Worcester; North Staffordshire; Shropshire; South Birmingham; South Staffordshire; Warwickshire, Solihull & Coventry; Nottingham; North Nottinghamshire; Lincoln; North Derbyshire; South Derbyshire; Leicester; Kettering; Northampton; Newcastle; North Tees; North Cumbria; Humberside; Pennine; Leeds Wakefield; North Yorkshire; Barnsley; Doncaster; Rotherham; Sheffield; South Essex; Bedfordshire & Hertfordshire; Epping; Chelmsford & Colchester; Southampton & Salisbury; Isle of Wight; North and Mid Hampshire; Portsmouth; Aylesbury & Wycombe; Milton Keynes; East Berkshire; West Berkshire; Oxfordshire; Bolton; Chester; Crewe; East Lancashire; Greater Manchester; Liverpool; East Cheshire & Stockport; North Lancashire; Warrington & Whiston; South Lancashire; Wirral; Avon; Cornwall; Dorset; Gloucestershire; Somerset; South Devon; West Devon & East Cornwall; Wiltshire; Barking, Havering, Redbridge & Brentwood; Central & East London; North London; South East London; South West London; West London; East Sussex, Brighton & Hove; Jarvis, Guildford; West Sussex, Worthing; Canterbury, Medway & Maidstone.

Investigators

AgeX was planned and conducted throughout its randomisation phase by researchers from the Cancer Epidemiology Unit and from the Early Breast Cancer Trial Collaborative Group, both of which are part of the University of Oxford Nuffield Department of Population Health (NDPH).  AgeX continues to be conducted by researchers from NDPH and the current investigators are: Associate Professor Toral Gathani (chief investigator); Associate Professor Isobel Barnes (deputy chief investigator); Krys Baker (AgeX co-ordinator); Dr Gurdeep Mannu; Associate Professor Hongchao Pan (AgeX statistician); Professor Julietta Patnick; Professor Richard Peto (statistical consultant); Professor Gillian Reeves; Keith Shaw (AgeX data manager); Professor Carolyn Taylor; Associate Professor Jane Wolstenholme.

Acknowledgements

We thank the women who participate and the staff of the participating breast screening units for their collaboration. Valerie Beral was the Principal Investigator and Kath Moser a co-investigator. Lucy Carpenter, Janet Darbyshire, Kevin Fenton, Sema Goldney, Annie Hogg, Jacquie Jenkins, Iain Lyburn, Tom Meade, Amanda Ramirez, Sarah Sellers, Margot Wheaton, Robin Wilson and Richard Winder were members of trial committees.

Data Monitoring and Ethics Committee

Professor Stephen MacMahon (Chair), Founding Director, George Institute for Global Health (trialist, epidemiologist); Professor Abdel Babiker, MRC Clinical Trials Unit, University College, London (trialist, statistician); Dr Ros Given-Wilson, St Georges Hospital, London (consultant breast radiologist); Professor Alison Halliday, Nuffield Department of Surgery (surgeon, surgical trialist); Ms Jenny Rusby, Royal Marsden Hospital, London (consultant breast surgeon).

Trial Management Group

Julietta Patnick (chair); Krys Baker (co-investigator); Isobel Barnes (deputy chief investigator); Jillian Boreham (lay member); Clare Borelli, NHS Breast Screening Programme (radiographer); Philip Clarke, NDPH (health economist); Toral Gathani (chief investigator); Robert Hills, NDPH (statistician); David Hunter, NDPH (epidemiologist); Anneke Lucassen, University of Oxford Nuffield Department of Medicine (clinical geneticist); Gurdeep Mannu (co-investigator); Hongchao Pan (co-investigator); Richard Peto (co-investigator); Malcolm Reed, Brighton and Sussex Medical School (surgical oncologist); Gillian Reeves (co-investigator); Keith Shaw (co-investigator); Carolyn Taylor (co-investigator); Sian Taylor-Philips, Warwick Medical School (population health researcher); Suzanne Wright, Intelligence and Research Lead, NHS England; Louise Wilkinson, NHS National Speciality Adviser for Breast Screening and Consultant Radiologist; Jane Wolstenholme (co-investigator).

Further information is available from the AgeX website.

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