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A previous paper in this journal reported that first pregnancy was followed by a marked decrease in dehydro-epiandrosterone sulfate (DHAS) and dehydroepiandrosterone (DHA) levels. We report here confirmatory observations from cross-sectional measurements in 460 women. In premenopausal subjects (n = 306), the mean DHAS level was 21% lower (P = 0.005) and the mean DHA level was 32% lower (P less than 0.001) in parous than in nulliparous women. Neither DHAS nor DHA was related to parity in postmenopausal women (n = 154).

Original publication




Journal article


J Clin Endocrinol Metab

Publication Date





1651 - 1653


Adult, Age Factors, Aged, Body Mass Index, Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, Female, Humans, Menopause, Middle Aged, Parity