The Premenopausal Breast Cancer Collaboration: A pooling project of studies participating in the National Cancer Institute Cohort Consortium.
Nichols HB., Schoemaker MJ., Wright LB., McGowan C., Brook MN., McClain KM., Jones ME., Adami HO., Agnoli C., Baglietto L., Bernstein L., Bertrand KA., Blot WJ., Boutron-Ruault MC., Butler L., Chen Y., Doody MM., Dossus L., Eliassen AH., Giles GG., Gram IT., Hankinson SE., Hoffman-Bolton J., Kaaks R., Key TJ., Kirsh VA., Kitahara CM., Koh WP., Larsson SC., Lund E., Ma H., Merritt MA., Milne RL., Navarro C., Overvad K., Ozasa K., Palmer JR., Peeters PH., Riboli E., Rohan TE., Sadakane A., Sund M., Tamimi RM., Trichopoulou A., Vatten L., Visvanathan K., Weiderpass E., Willett WC., Wolk A., Zeleniuch-Jacquotte A., Zheng W., Sandler DP., Swerdlow AJ.
Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual studies and resulting low statistical power to subcategorize exposures or to study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established to facilitate cohort-based analyses of risk factors for premenopausal breast cancer by pooling individual-level data from studies participating in the United States National Cancer Institute Cohort Consortium. This paper describes the Group, including the rationale for its initial aims related to pregnancy, obesity, and physical activity. We also describe the 20 cohort studies with data submitted to the Group by June 2016. The infrastructure developed for this work can be leveraged to support additional investigations.