Adaptation to changes in routine breast screening
During 2018, the NHS BSP improved its IT systems, adjusting which women would be invited for routine screening and hence adjusting which other women could therefore be invited into the AgeX trial (Annex 1). If, as may well be the case, further improvements in BSP software lead to any further adjustments in eligibility for routine screening, then these will automatically result in further adjustments to recruitment into the trial, to avoid any possibility of overlap in future years between eligibility for routine screening and eligibility for AgeX.