Investigators and participating breast screening units
Participating breast screening units
City, Sandwell & Walsall; Dudley & Wolverhampton; Hereford & Worcester; North Staffordshire; Shropshire; South Birmingham; South Staffordshire; Warwickshire, Solihull & Coventry; Nottingham; North Nottinghamshire; Lincoln; North Derbyshire; South Derbyshire; Leicester; Kettering; Northampton; Newcastle; North Tees; North Cumbria; Humberside; Pennine; Leeds Wakefield; North Yorkshire; Barnsley; Doncaster; Rotherham; Sheffield; South Essex; Bedfordshire & Hertfordshire; Epping; Chelmsford & Colchester; Southampton & Salisbury; Isle of Wight; North and Mid Hampshire; Portsmouth; Aylesbury & Wycombe; Milton Keynes; East Berkshire; West Berkshire; Oxfordshire; Bolton; Chester; Crewe; East Lancashire; Greater Manchester; Liverpool; East Cheshire & Stockport; North Lancashire; Warrington & Whiston; South Lancashire; Wirral; Avon; Cornwall; Dorset; Gloucestershire; Somerset; South Devon; West Devon & East Cornwall; Wiltshire; Barking, Havering, Redbridge & Brentwood; Central & East London; North London; South East London; South West London; West London; East Sussex, Brighton & Hove; Jarvis, Guildford; West Sussex, Worthing; Canterbury, Medway & Maidstone.
Investigators
Dr Toral Gathani (chief investigator), University of Oxford Nuffield Department of Population Health (NDPH) ; Professor Isobel Barnes (deputy chief investigator), NDPH; Krys Baker (trial co-ordinator), NDPH; Dr Gurdeep Mannu, NDPH; Professor Hongchao Pan, NDPH; Professor Julietta Patnick; Professor Richard Peto, NDPH; Professor Gillian Reeves, NDPH; Keith Shaw (trial analyst), NDPH; Professor Carolyn Taylor, NDPH.
Acknowledgements
This trial will take more than a decade to answer the questions it addresses. We thank the women who participate and the staff of the participating breast screening units for their collaboration. We thank Valerie Beral, Kath Moser and Mike Richards, who were co-investigators. We also thank Lucy Carpenter, Janet Darbyshire, Kevin Fenton, Iain Lyburn, Tom Meade, Amanda Ramirez, Sarah Sellers, Margot Wheaton, Robin Wilson and Richard Winder, who were members of trial committees.
Trial Management Group
Julietta Patnick (chair); Krys Baker (co-investigator); Isobel Barnes (deputy chief investigator); Jill Boreham (lay member); Clare Borelli, NHS Breast Screening Programme (radiographer); Toral Gathani (chief investigator); Sima Goldney (lay member); Professor Robert Hills, NDPH (statistician); Professor David Hunter, NDPH (epidemiologist); Jacquie Jenkins, National Programme Manager for Breast Screening, NHS England; Gurdeep Mannu (co-investigator) Hongchao Pan (co-investigator); Richard Peto (co-investigator); Professor Malcolm Reed, Dean of Brighton and Sussex Medical School (surgical oncologist); Gillian Reeves (co-investigator); Keith Shaw (co-investigator); Carolyn Taylor (co-investigator); Professor Sian Taylor-Philips, Warwick Medical School (population health researcher); Suzanne Wright, Technical/System Product Owner, Intelligence and Research Lead, NHS England.
Data Monitoring and Ethics Committee
Professor Stephen MacMahon (Chair), Founding Director, George Institute for Global Health (trialist, epidemiologist); Professor Abdel Babiker, MRC Clinical Trials Unit, University College London (trialist, statistician); Dr Ros Given-Wilson, Medical Director, St Georges Hospital, London (breast radiologist); Professor Alison Halliday, Nuffield Department of Surgery (surgeon, surgical trialist); Ms Jenny Rusby, Royal Marsden Hospital, London (consultant breast surgeon).
Sponsor
University of Oxford
Funding
Department of Health funds are allocated to Public Health England for this trial. Data analysis is funded from the quinquennial core support for the Cancer Epidemiology Unit and for the Clinical Trial Service Unit (both in the University of Oxford’s Nuffield Department of Population Health, NDPH) from the Medical Research Council and Cancer Research UK.
Approvals and permissions
Ethical approval in 2010, 2014, 2016 and 2018 for AgeX (formerly called the Age Extension Trial) was from Ealing & West London (now Harrow) Research Ethics Committee (ref 10/H0710/9). Section 251 support for use of patient-identifiable data without consent and for access to medical records by those outside the healthcare team was from the National Information Governance Board Ethics & Confidentiality Committee (ECC 1-04 (b)/2010). Additional approvals were granted for the five breast screening units that participated in the pilot study to become part of the main trial, and for linkage of breast screening records from the trial to other records (in addition to the cancer and death registration records included in the original application).