Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer
Established in 2004
Data from 36,000 cases in over 40 studies worldwide
The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group conducts pooled analyses of the relationships between endogenous sex hormones, insulin-like growth factors, nutritional biomarkers and subsequent prostate cancer risk.
For most biomarkers, there is sufficient statistical power to analyse the associations subdivided by tumour subtypes, disease aggressiveness and other patient characteristics, which cannot be done in any one individual cohort study. The group was established in 2004 with its secretariat in the Cancer Epidemiology Unit, and it is co-directed by Prof Tim Key and Associate Professor Naomi Allen.
Scientists from 39 studies worldwide are collaborating in this work. So far the project has collected data from around 36,000 men with prostate cancer and over 56,000 control men for more than 50 biomarkers. This collaborative group has published highly cited research on the association of prostate cancer risk with circulating levels of sex hormones, IGFs, testosterone, isoflavones, vitamin D, carotenoids and tocopherols, fatty acids, folate and vitamin B12 and selenium, with analyses of other biomarkers underway.
The EHNBPCCG had its first meeting in July 2005 and its second in 2012. The third collaborators' meeting was held in March 2018 in Oxford.